Now vinyl and cd audio quality is a different story for another time lol. I'm sure there's some diehard audiophiles out there somewhere that will claim there's a difference though. If I truly can't tell the difference between frontpanel usb/back panel audio jacks then I don't see how anyone else can if you have the software/hardware option for either one. My bio father (long story) was a musician and trained me to have perfect pitch from a very young age-he used me to fine tune/mix-down/master all his final studio mixes before he played them live. Originally posted by Eshman:I have my Logitech gaming headset plugged into a back usb port on my mid-tower and it really sounds just great-I can listen to anything I want and still use my mic without any problems.